Agmatine Sulfate: Benefits, Side Effects, Best Time to Take It & More

Agmatine Sulfate

(Agmatine)

Evidence: High
Possible Benefits: High
Safety: Reasonable

What is agmatine sulfate?

Agmatine is a metabolite of L-arginine. Agmatine sulfate is a form of agmatine and a popular dietary supplement mainly used for improving exercise performance. This article is about the main benefits of agmatine sulfate, its potential side effects, the best time to take it, and more.

Possible benefits

All of the potential benefits mentioned below are dose-dependent. As with most other supplements, there is a sweet-spot dose that allows you to get most of the benefits without causing meaningful side effects or tolerance buildup in the body. We will discuss the best dosing protocol later in this article.

Major benefits

Reduced pain – One human study found a great reduction in pain related to lumbar disc-associated radiculopathy. The pain reduction lasted for at least two months after the participants stopped taking agmatine. This benefit may apply to other causes of physical pain but more evidence is needed.
Reduced addiction – Agmatine supplementation can be very helpful for people physically addicted to opioids and alcohol. The supplement can reduce tolerance to these substances and reduce symptoms of withdrawal.

Minor benefits

Improved well-being – Very limited human research suggests agmatine may have anti-depressive effects at doses of 2-3 grams. It is not yet clear whether or not doses this high are safe and until more safety research comes about, it is probably best to stay below a gram of agmatine daily.
Improved cognition – This benefit is mostly anecdotal so far and may occur at doses of 1.6-6.4 mg/kg.

Possible side effects

The side effects below are dose-dependent. The risk for them increases (often linearly but sometimes exponentially) as you increase the dose. Some of the side effects only apply to very high doses.

Allergic reaction – An allergy to this supplement is rare but possible.
Nausea – This side effect is most common when people take the supplement on an empty stomach.
Diarrhea – You can usually prevent diarrhea or stomach discomfort by taking this supplement with a meal.
Toxicity – While acute toxicity is extremely rare, taking high amounts of this supplement could lead to chronic toxicity and cause health problems over time. Regularly taking high doses can also cause the body to develop a tolerance to the supplement. To prevent chronic toxicity or the buildup of tolerance, staying below one gram in a day is best unless you have a great reason to take more.
Contamination – Contaminated supplements are uncommon in the USA and other well-regulated countries. However, if you wish to buy products from China, India, or other countries without strict regulations, beware that the supplements may be contaminated. Either way, you need to choose the brand you order from wisely. Always read through some reviews for the specific product before you buy it. The FDA (Food and Drug Administration) has the power to regulate dietary supplements but can only do so after they have been on the market for a while. That’s because supplement companies are not obligated to announce to the FDA when releasing a new product. The FDA has to discover the product and test it for potential impurities, which can take a lot of time. During that time, the supplement can be sold on the market even if it’s impure. Also, supplement companies can change their manufacturers without announcing it to the FDA.

Who should not take agmatine sulfate?

You should probably avoid taking agmatine sulfate if you:

are allergic to this supplement
experience a severe adverse reaction after taking the supplement
are pregnant or breastfeeding (while it can be safe to take this supplement during pregnancy or breastfeeding, it can put some unnecessary risk to the child)

Who will benefit the most?

You should consider taking the supplement if you:

are addicted to opioids or alcohol
experience lots of pain
suffer from depression
have a high budget for supplements and are willing to experiment with a variety of them (assuming you don’t fall into any of the categories that should avoid this supplement, agmatine sulfate appears relatively safe and is unlikely to do more harm than good for most people)

How much agmatine sulfate should you take?

The sweet spot dose typically ranges between 300-600 mg daily for most people. This amount should provide most of the benefits without meaningful side effects.

The higher end of this range usually provides slightly more benefits in the short term. If you plan to take this supplement for a longer time (multiple months or years), the lower end is probably a better way to go since it is safer, and you would develop tolerance faster if you were to take higher doses.

The upper safety limit for this supplement is not well-established. To stay on the safe side, don’t take more than the recommended dose unless you have a great reason to do so. Higher amounts may cause problems if you take the supplement for a prolonged period.

Like most other supplements, it is best to cycle agmatine sulfate and take about two days off weekly to reset your tolerance. That will allow you to keep getting the benefits in the long term.

Best time to take agmatine sulfate

Agmatine may compete for absorption with dietary protein so it is best to take the supplement at least 2 hours before or after a meal.

Whether you take the supplement in the morning or the evening does not make much difference. Both options are fine so feel free to experiment.

Agmatine sulfate is water-soluble, so you don’t have to take it with food to absorb it well.

Interactions

Marijuana
This combination appears synergistic for reducing pain.
Opioids
Agmatine can reduce tolerance to opioids and perhaps other sedative and opioid-like substances.
Alcohol
The supplement can reduce symptoms of alcohol withdrawal.
Protein
Agmatine may compete for absorption with arginine and other amino acids so it is best to take the supplement at least 2 hours before or after a meal.

Where to buy agmatine sulfate?

In most countries, Amazon is the best option for ordering agmatine sulfate supplements. They offer some very affordable products backed by many positive reviews. Also, you can choose from a wide range of brands without having to search through other markets on the Internet.

Some brands display the dosage per serving instead of per pill or capsule. Therefore, you may accidentally buy something less potent than you intended. Do not fall for this marketing trick.

FAQ

Like most other supplements, it is best to cycle agmatine sulfate and take a break from it for about two days per week to reset your tolerance back to baseline. That will keep your body sensitive to the supplement and allow you to keep getting the benefits in the long term.

All of these options are fine. The two most important things to consider are the price and dosing. Powders are almost always the cheapest form. However, you may need a highly accurate scale to dose them correctly (preferably 0.001g). You can get one for as little as $20 from Amazon. Dosing the powders also takes time which can add up over months or years. The disadvantage of capsules is that they are often made of bovine gelatine, which rarely comes from ethical sources.

While you could take the supplement at night, the best time to take it is before or during an exercise session.

This supplement should not become harmful once it exceeds the expiration date. However, it can lose potency over time. Keep this supplement in a cold, dark, and dry place so it remains as potent for many months or even years.

While acute toxicity is rare, taking very high amounts of this supplement could lead to various problems over time. High doses can also make you develop tolerance much faster than lower doses.

While you could safely take higher doses, there is usually no point in taking more than a gram daily. This amount should give you most of the benefits without meaningful side effects.

The half-life of agmatine sulfate in the body is about 12 hours. This supplement gets metabolized within two days after you consume it.

Some benefits related to exercise performance happen right after the supplement kicks in. In the long term, you must take the supplement for about 2-4 weeks to begin noticing most of the benefits.

You can easily find vegan-friendly agmatine sulfate pills and powders but always check the label to be sure. If you buy the supplement in a capsulated form, beware that the capsules often contain animal-based gelatin. Instead, find a brand that puts its products into cellulose capsules.

No, it does not. The supplement should not interfere with fasting in any significant way.

References

Most of the information in this guide is based on scientific research that can be found and verified in the PubMed medical library. We highly encourage you to use the library to verify anything you read in this article. We excluded from consideration studies that are either confounded or have a high conflict of interest.

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